The former Amtrak station in Dearborn, Michigan, is being converted into an animal shelter.
It will replace another shelter the group has used for more than 30 years.
Amtrak used the station until December 2014 when the Chicago-Detroit (Pontiac) Wolverine Service trains began stopping at the new John D. Dingell Transit Center.
Officials said renovation of the Amtrak into an animal shelter will be done in two steps and cost $5.7 million.
The first stage will involve 10,000 square feet of space, including dog and cat housing, expanded adoption services and a storage area.
The second stage will add 6,000 square feet of space for animal intake and evaluation, medical facilities and administrative space.
The group said it has railed $4.7 million of the money needed to transform the station.